Based on the book Annie's Box, penned by Charles Darwin's great-great-grandson Randal Keynes, which is itself based on personal letters and diaries from his family, Creation is essentially a love story that offers a unique perspective into the life of Darwin and his family, and, in particular, the love he had for his wife. Deeply religious, she is torn between her faith and the scientific beliefs upheld by her husband. The narrative takes place as Darwin struggles to finish his seminal publication, On the Origin of Species, which goes on to become the foundation for evolutionary biology.