Set in the Melbourne suburb of Camberwell during World War Two, The Sullivans follows the lives of Dave and Grace Sullivan and their children John, Tom, Dave, and Kitty. However, the storylines reach beyond the immediate Sullivan family, allowing viewers to see their extended family, friends, and neighbours also struggle through everyday war-time life.
The series also featured war-action sequences involving various characters. Arguably the most dramatic moment, and the event that effectively became a turning point in the series, was the death of Grace Sullivan in a London air raid. The series finished after a seven-year run, by which point most of the original cast had left the series and the remaining characters had settled into a new life in the post-war era.