Crawford Vaughan worked as a clerk, visited the West Australian goldmines and was a freelance journalist before entering South Australian politics. He was elected MP for Torrens (1905-15), MP for Sturt (1915-18), before becoming Premier of South Australia, Treasurer and Minister for Education (1915-1917) at the age of 40.
Political infighting lost Vaughan the majority and after his time in politics, he travelled and gave lectures internationally, invited by the government of the United States of America, for example, to speak to American industrialists about supporting the war effort. From 1920, lived in Sydney and worked in business, married his second wife, the prominent feminist Millicent Preston Stanley, in Melbourne and worked in Adelaide again in the 1930s as chief leader-writer for the News. He wrote radio plays and published two works of historical fiction.