Henry Hussey migrated to Adelaide from England with his family in 1839. He trained from 1841 as a printer in the business of George Dehane, and as a compositor with the Adelaide Observer and the South Australian Register, newspapers which he printed and published in the 1850s. He purchased the printing business of John Stott, in King William Street, Adelaide, and was active as a printer in his own right until 1853, when he joined in a printing partnership as Hussey and Shawyer, which became Hussey, Shawyer and Gall in 1855, and Hussey and Gall in 1856. After that time Gall continued the business on his own as David Gall.
Henry Hussey became a lay preacher, an evangelist, and a pastor at the undenominational church in Bentham, Street, Adelaide. He published a number of evangelical journals, and sold religious material at a Bible Hall and Tract Depot which he established in Adelaide. Hussey wrote a biography of George Fife Angas, for whom he worked as secretary until Angas' death in 1879; he also wrote a history of South Australia, published in 1893, and an autobiography, More than Half a century of Colonial Life and Christian Experience (1897).
George Frederick Hussey, a nephew of Henry Hussey, trained as a printer with David Gall, and established the firm Hussey and Gillingham in Adelaide with J. R. Gillingham in 1888.