After graduating with an Arts/Law degree at the University of New South Wales, John Misto initially worked as a solicitor with the New South Wales Privacy Committee. He began his career as a full-time writer in 1981 and has since produced numerous award-winning scripts for both television and stage; his output as a playwright includes The Shoe-Horn Sonata (1996) and 'Harp on the Willow' (2002).
Misto's career has also seen him establish his reputation as a television scriptwriter. Among his credits are a number of mini-series and telemovies, including Palace of Dreams (1985), The Last Frontier (1986), The Dirtwater Dynasty (1988), The Fremantle Conspiracy (1988), Butterfly Island (1993: a film sequel to the television series Butterfly Island), Finding Hope (2001), The Day of the Roses (2001), Heroes' Mountain: The Rescue of Stuart Diver (2002), Second Chance (2005), and Sisters of War (2010), as well as Peter and Pompey, a telemovie that formed part of the Australian Children's Television Foundation anthology series Touch the Sun and was later published as a novel for young adults.
His scripts for serial television include work on Waterloo Station (1983), The Young Doctors (1983), Dancing Daze (1986), Dusty (1988), G.P. (1989-1991), A Country Practice (1991), The Damnation of Harvey McHugh (1994), MDA (2002), White Collar Blue (2003), The Cut (2009), and Tricky Business (2012).
Misto's first novel intended for an adult readership, The Devil's Companions, was published in 2005.
In 2010, Misto won the Television Script - QUT Creative Industries Award in the Queensland Premier's Literary Awards for his World War II documentary Sisters of War.