Wendy James received a Bachelor of Arts from the University of Sydney and studied for an MA in writing at the University of Technology, Sydney. She has undertaken PhD studies at Deakin University, Victoria. In 2018, she was working as an editor at the Australian Institute of Health Innovation.
James won the University of Sydney Union/AAP short story competition in 1994 and 1995. Her 2005 debut novel Out of the Silence won the Ned Kelly Award for a Best First novel, and was shortlisted for a Dobbie Award. Her subsequent novels have regularly appeared on the longlists and shortlists for Australia's major crime-fiction awards, the Ned Kelly Awards and the Davitt Awards.
James, one of three sisters, is the sister of Rebecca James.