Kate Weston and her husband John Samuel Weston, married in Adelaide in 1885, and moved there in 1892. Widowed in 1894, Weston turned to writing to provide financially for herself and her children. She contributed to many Australian newspapers, and published fiction between 1911 and 1928. She was music and art critic for The Register, contributed to The Woman's Record - a monthly publication - and, according to her obituary in The Advertiser, she was the 'founder of community singing in Adelaide'. She was Lady Superintendent of the Elder Conservatorium in Adelaide between 1900 and 1914, her daughter Mignon taking over the position when she left. Her grandson has indicated that Kate Weston was the first woman to work in insurance in South Australia.
Weston lived in South Terrace, Adelaide, and contested a ward in local government elections in 1923. She took an active interest in matters relating to the education of women, and was President of the Liberal Women's Educational Association and involved in the Housewives' Association. On the evening of Monday, 11th June 1929 she fell while alighting from a tram in North Terrace, possibly travelling to the meeting of the Liberal Women's Educational Association which was held at the Liberal Club Hall that night. She was taken to the Royal Adelaide Hospital where she died on the 1st August without regaining consciousness.