Paul Langton Grano attended school in Ararat, Victoria, and later at St Patrick's College, Ballarat, before going on to the University of Melbourne in 1912. He graduated in law in 1916. Grano practised law in Stawell for a short period. On 11 December 1919 he married professional musician Vilet Irene Galloway. The couple had a son and twin daughters.
Although he published some early poetry in Melbourne University Magazine and the Bulletin Grano's career as a poet did not really begin until he moved to Brisbane in the early 1930s and published his first volume of poetry, Poems Personal and Otherwise, in 1933. He became a respected member of a group of Brisbane poets publishing at the time, including James Picot, Brian Vrepont, Martin Haley, Frank Francis and James Devaney, and seven of his poems were included in the first edition of Meanjin Quarterly in 1940. In 1944 he was a founder of the Catholic Readers' and Writers' Society in Brisbane which encouraged young writers and published the periodical Vista. In 1946 Grano edited Witness to the Stars, an anthology with notes on living Australasian Catholic poets.
From 1939 until his retrenchment in 1953 Grano was employed by the Queensland Main Roads Commission, the last three years in Townsville. He then worked with the Queensland Housing Commission from 1954 to 1960. On 5 December 1959 he married his second wife, Bobs Victoria Sears, with whom he had one daughter.
Much of Grano's verse was concerned with religious faith and themes. His last few years were spend in Canossa, a Catholic institution.
