Pat Lowe taught in France and East Africa before studying psychology at Liverpool University. She migrated to Australia in 1972, gained a Master's degree from the University of Western Australia, worked as a clinical psychologist at the Fremantle Prison in late 1970s and moved to the Kimberley region in 1979.
In 1986 Lowe joined the late Jimmy Pike (q.v.), an Aboriginal artist, at his camp in the Great Sandy Desert and during the next three years, they hunted and explored much of the country Pike knew as a boy. Lowe and Pike later lived in Broome where they collaborated on several books. It was through Pike that Lowe met his nieces, Ngarta and Jukuna, about whom she has written in Two Sisters: Ngarta and Jukuna (2004).