Born in Sir Lanka, Michelle de Kretser was educated at Methodist College, Colombo, before migrating to Australia with her family in 1972, when she was 14. After completing high school in Melbourne, she studied French at the University of Melbourne. De Kretser subsequently taught for a year at Montpellier and enrolled for an MA in Paris.
After returning to Australia, de Kretser worked for many years as an editor for the travel publisher, Lonely Planet, for which, in 1998, she edited the short story and travel writing anthology Brief Encounters : Stories of Love, Sex and Travel. She was also a founding editor of the Australian Women's Book Review (1989-1992).
In the late 1990s de Kretser used long-service leave from Lonely Planet to write her first novel, The Rose Grower (1999). Her following novels were The Hamilton Case (2002), The Lost Dog (2007), Questions of Travel (2012), Springtime : A Ghost Story (2014), and The Life to Come (2017). Her novels have won a range of Australian and international awards, including the Commonwealth Writers Prize, the Frankfurt Literaturpreis, the NSW Premier's Literary Awards (multiple times), the ALS Gold Medal, the Miles Franklin Award, and the Prime Minister's Literary Award. They have also been shortlisted for prestigious awards, including the Barbara Jefferis Award and the Stella Prize, and have been taught at universities across Australia.