Bob Weis began his career in the Australian film and television industries in the early 1970s and has also been involved in producing feature films and television programs in Europe and the United States of America. For a number of years during the late 1970s and early 1980s, however, Weis was primarily involved with the Pram Factory theatre in Melbourne . He also helped establish the cultural and training organisation Open Channel. In 1979 Open Channel's children's show, Stax, was launched by HSV7. Promising a new approach to television (where children, aged 7 to 13 provided the ideas for the show and presented them) the program was produced by Weis.
Among the film and television works he has produced for his own company, Generation Films, are: Daddy Cool (1973 documentary), Women of the Sun (1981), The Clinic (1992), Waterfront (1984), The Seven Deadly Sins (1992, TV series), Lucky Break (1994) and Paperback Romance (1997). He has also been engaged as producer for: Pure Shit (1975), The Dunera Boys (1984, TV miniseries), The Empty Beach (1985, as Executive Producer), The Petrov Affair (1987) and Cassidy (1989, telemovie).
As a director Weis has worked on Wills and Burke: The Untold Story (1985) and Women of the Sun: 25 Years Later (2006). In 1988 he also co-wrote with Joanna Murray-Smith (q.v.) the screenplay for Georgia (1988).
Weis' career in the Australian film industry has seen him take on such positions as Council Member of the Australian Film TV and Radio School (1984-1990), Chairman of the Australian Film Institute (1995-1998), and President of the Screen Producers Association of Australia (1991-1994). He has also been a Board Member of Museums Victoria and Chair of its Technology, Information and Multi-Media Committee, Chairman of the Australian Art Orchestra and a member of the Koorie Heritage Trust.