Esther Anatolitis has been the CEO of the Melbourne Fringe festival in Victoria and the co-curator of Architecture+Philosophy. She was chair of the Arts Industry Council (Victoria) (2008-2010), director of Regional Arts Victoria, and CEO of Express Media, in which role she was a founder of the Emerging Writers' Festival. She has been a Voiceworks publisher and a founding partner of the Small Press Network.
In 2018, Anatolitis was Executive Director of NAVA and Deputy Chair of Contemporary Arts Precincts. In 2022, she was announced as the next editor of Meanjin, following Jonathan Green's departure with the December 2022 edition.