Andrea Bresciani was born in the former Slovenian town of Tolmin, which, after World War I, was renamed Tolmino and absorbed into the Italian province of Gorizia. Bresciani began his career as a commercial artist in Milan, designing furniture for a local architect. Upon reading a discarded comic book on a train shortly after World War II, Bresciani decided to seek additional work as a comic-book artist. After spending three months preparing a folio of comic-book illustrations, Bresciani secured employment as an artist with the publisher Edizioni Alpe (Milan).
Throughout 1945-1950, Bresciani worked for several Italian comic-book publishers, illustrating adventure serials for the cheap 'piccolo' (pocket-sized) comics that flourished in Italy and elsewhere in Europe after the war. Amongst Bresciani's best-known works from this period were Geky Dor and Tony Falco.
Bresciani migrated to Australia ca.1950, arriving in Perth and settling in Sydney in 1951. He initially worked for Atlas Publications (q.v.), illustrating stories for Squire: A Man's Magazine and producing innumerable covers for pulp fiction magazines (see Badlands Western - The Right Fork) and comic books (e.g., Flynn of the FBI and The Wraith). Bresciani occasionally drew entire issues of comic books for Atlas Publications, including Sergeant Pat of the Radio Patrol and The Ghost Rider.
With the closure of Atlas Publications in the late 1950s, Bresciani became a freelance illustrator for K. G. Murray (q.v.), contributing artwork to various men's magazines, including Man, Adam, and Pocket Man. Bresciani also drew several issues of The Adventures of Smoky Dawson (Colour Comics Pty Ltd, ca.1960), portraying the Australian country-and-western singer Smoky Dawson (q.v.) in fictional adventures. The series was previously drawn by Albert De Vine, who originally developed the comic as a newspaper feature for the Sydney Sun (ca.1959).
Bresciani remains best known for his work on the Australian comic strip Frontiers of Science, which he illustrated throughout 1961-1970. Conceived as an educational series by Professor Stuart Butler (University of Sydney) and written by journalist and filmmaker Bob Raymond, Frontiers of Science debuted in the Sydney Morning Herald and was syndicated to 200 newspapers worldwide.
Bresciani returned to Europe in the early 1970s, initially working as a comic-book artist for various Spanish and German publishers, before embarking on a new career as a production designer and layout artist on animated cartoons. Bresciani returned to Sydney in the early 1980s, working for Hanna-Barbera Productions' Australian studio. In 1981, Bresciani relocated to Manila. Establishing an animation studio for Marvel Productions, he worked on the television series Defenders of the Earth (1986). Returning to Australia, Bresciani continued working as a layout supervisor and animation director on animated feature films and television series until the late 1990s. In his retirement, Bresciani devoted himself to creating sculptures of horses, which were in great demand in Japan, France, and the United States.
