Samuel Genocchio was born in Melbourne and grew up in Sydney. He studied at the Australian Film Television and Radio School and then began work as a writer for the television program Neighbours. Genocchio worked as a freelancer in a range of creative arts roles, including director, writer and producer for film, television, theatre and events, but the majority of his work was as a screenwriter. Genocchio was co-founder of Short and Sweet, the largest short play festival in the world.