In the year 4000AD, after suffering a terrible injury, Andra receives a brain transplant from a donor who died in 1987. With this new brain tissue, she realises for the first time how repressive her world's regime is, and leads a rebellion against the ruling powers.
Like many relatively short-lived programs from the 1970s, Andra is now extremely obscure: as with its predecessor Alpha Scorpio, rumours abound that the master tapes have been destroyed.
Andra is also subject to a number of misconceptions. Albert Moran, for example, notes that the program is a sequel to Alpha Scorpio. (Nor is Moran the only source for this statement.) Andra, which is based on a novel by British writer Louise Lawrence, is Alpha Scorpio's sequel only in that the ABC were seeking a science-fiction program aimed at young female viewers, just as Alpha Scorpio was aimed at young male viewers.