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A 'what if?' anthology, centred on the question What if Sherlock Holmes had a different offsider than Doctor Watson?
Some of the doctors are fictional and drawn from either other novelists' works (e.g., Dr Henry Jekyll [Robert Louis Stevenson] and Dr Antonio Nikola [Guy Boothby], some are fictional and drawn from Conan Doyle's own work (e.g., Dr Grimesby Roylott [from 'The Adventure of the Speckled Band']), and some are historical (e.g., Dr John Dee, Doc Holliday, and Conan Doyle himself).