Raimondo Cortese was born to an Italian father (who migrated from Ascoli Piceno in 1952) and an Anglo-Celtic mother. A speaker of some Italian and Spanish, he initiated a visual poetry performance night at the Bakers Cafe Melbourne and has given numerous exhibitions of his work there. He has also exhibited his work at the 1989 St Kilda's Writers Festival, at 1990 Vast performance nights, at the 1990 Next Wave Writers Festival, and at Lord Jims in Melbourne in 1990, and also held a solo exhibition in Pisa, Italy in 1991.
From 1994 to 2001, he was artistic director of Ranters Theatre, of which he was one of the co-founders. In 2014, Cortese completed his PhD. In 2018, he was heading the Master of Writing for Performance at the Victorian College of Arts.
His works have won the Green Room Award for Best Australian Writing, and he was the inaugural winner of the Patrick White Playwrights' Fellowship.